SrasV1, Main, Exploration, bibRecord, 005A76

Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires stat1

Identifieur interne : 005A76 ( Main/Exploration ); précédent : 005A75; suivant : 005A77

Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires stat1

Auteurs : Robert J. Hogan [États-Unis] ; GUANGPING GAO [États-Unis] ; Thomas Rowe [États-Unis] ; Peter Bell [États-Unis] ; Douglas Flieder [États-Unis] ; Jason Paragas [États-Unis] ; Gary P. Kobinger [États-Unis] ; Nelson A. Wivel [États-Unis] ; Ronald G. Crystal [États-Unis] ; Julie Boyer [États-Unis] ; Heinz Feldmann [Canada] ; Thomas G. Voss [États-Unis] ; James M. Wilson [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2004.

RBID : Pascal:04-0554030

Descripteurs français

KwdFr :
- Animaux, Bronchiolite virale (virologie), Facteur de transcription STAT-1, Immunohistochimie, Poumon (anatomopathologie), Poumon (virologie), Protéines de liaison à l'ADN (génétique), Protéines de liaison à l'ADN (métabolisme), Souris, Syndrome respiratoire aigu sévère (anatomopathologie), Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (physiopathologie), Syndrome respiratoire aigu sévère (virologie), Transactivateurs (génétique), Transactivateurs (métabolisme), Virus du SRAS (pathogénicité).
MESH :
- anatomopathologie : Poumon, Syndrome respiratoire aigu sévère.
- génétique : Protéines de liaison à l'ADN, Transactivateurs.
- immunologie : Syndrome respiratoire aigu sévère.
- métabolisme : Protéines de liaison à l'ADN, Transactivateurs.
- pathogénicité : Virus du SRAS.
- physiopathologie : Syndrome respiratoire aigu sévère.
- virologie : Bronchiolite virale, Poumon, Syndrome respiratoire aigu sévère.
Pascal (Inist)
- Animaux, Coronavirus, Facteur de transcription STAT-1, Grave, Immunohistochimie, Malade état grave, Aigu, Souris, Voie respiratoire, Microbiologie, Virologie, Syndrome respiratoire aigu sévère, Forme grave.

English descriptors

KwdEn :
- Acute, Animals, Bronchiolitis, Viral (virology), Coronavirus, Critically ill, DNA-Binding Proteins (genetics), DNA-Binding Proteins (metabolism), Immunohistochemistry, Lung (pathology), Lung (virology), Mice, Microbiology, Respiratory tract, SARS Virus (pathogenicity), STAT1 Transcription Factor, Severe, Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (pathology), Severe Acute Respiratory Syndrome (physiopathology), Severe Acute Respiratory Syndrome (virology), Severe acute respiratory syndrome, Trans-Activators (genetics), Trans-Activators (metabolism), Virology.
MESH :
- chemical , genetics : DNA-Binding Proteins, Trans-Activators.
- chemical , metabolism : DNA-Binding Proteins, Trans-Activators.
- immunology : Severe Acute Respiratory Syndrome.
- pathogenicity : SARS Virus.
- pathology : Lung, Severe Acute Respiratory Syndrome.
- physiopathology : Severe Acute Respiratory Syndrome.
- virology : Bronchiolitis, Viral, Lung, Severe Acute Respiratory Syndrome.
- Animals, Immunohistochemistry, Mice, STAT1 Transcription Factor.

Abstract

Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the lungs and the development of self-limited bronchiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Statl demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus in lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acute</term>
<term>Animals</term>
<term>Bronchiolitis, Viral (virology)</term>
<term>Coronavirus</term>
<term>Critically ill</term>
<term>DNA-Binding Proteins (genetics)</term>
<term>DNA-Binding Proteins (metabolism)</term>
<term>Immunohistochemistry</term>
<term>Lung (pathology)</term>
<term>Lung (virology)</term>
<term>Mice</term>
<term>Microbiology</term>
<term>Respiratory tract</term>
<term>SARS Virus (pathogenicity)</term>
<term>STAT1 Transcription Factor</term>
<term>Severe</term>
<term>Severe Acute Respiratory Syndrome (immunology)</term>
<term>Severe Acute Respiratory Syndrome (pathology)</term>
<term>Severe Acute Respiratory Syndrome (physiopathology)</term>
<term>Severe Acute Respiratory Syndrome (virology)</term>
<term>Severe acute respiratory syndrome</term>
<term>Trans-Activators (genetics)</term>
<term>Trans-Activators (metabolism)</term>
<term>Virology</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Bronchiolite virale (virologie)</term>
<term>Facteur de transcription STAT-1</term>
<term>Immunohistochimie</term>
<term>Poumon (anatomopathologie)</term>
<term>Poumon (virologie)</term>
<term>Protéines de liaison à l'ADN (génétique)</term>
<term>Protéines de liaison à l'ADN (métabolisme)</term>
<term>Souris</term>
<term>Syndrome respiratoire aigu sévère (anatomopathologie)</term>
<term>Syndrome respiratoire aigu sévère (immunologie)</term>
<term>Syndrome respiratoire aigu sévère (physiopathologie)</term>
<term>Syndrome respiratoire aigu sévère (virologie)</term>
<term>Transactivateurs (génétique)</term>
<term>Transactivateurs (métabolisme)</term>
<term>Virus du SRAS (pathogénicité)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA-Binding Proteins</term>
<term>Trans-Activators</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>DNA-Binding Proteins</term>
<term>Trans-Activators</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de liaison à l'ADN</term>
<term>Transactivateurs</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines de liaison à l'ADN</term>
<term>Transactivateurs</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Bronchiolite virale</term>
<term>Poumon</term>
<term>Syndrome respiratoire aigu sévère</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Bronchiolitis, Viral</term>
<term>Lung</term>
<term>Severe Acute Respiratory Syndrome</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Immunohistochemistry</term>
<term>Mice</term>
<term>STAT1 Transcription Factor</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Coronavirus</term>
<term>Facteur de transcription STAT-1</term>
<term>Grave</term>
<term>Immunohistochimie</term>
<term>Malade état grave</term>
<term>Aigu</term>
<term>Souris</term>
<term>Voie respiratoire</term>
<term>Microbiologie</term>
<term>Virologie</term>
<term>Syndrome respiratoire aigu sévère</term>
<term>Forme grave</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Intranasal inhalation of the severe acute respiratory syndrome coronavirus (SARS CoV) in the immunocompetent mouse strain 129SvEv resulted in infection of conducting airway epithelial cells followed by rapid clearance of virus from the lungs and the development of self-limited bronchiolitis. Animals resistant to the effects of interferons by virtue of a deficiency in Statl demonstrated a markedly different course following intranasal inhalation of SARS CoV, one characterized by replication of virus in lungs and progressively worsening pulmonary disease with inflammation of small airways and alveoli and systemic spread of the virus to livers and spleens.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Alabama</li>
<li>Maryland</li>
<li>Pennsylvanie</li>
<li>État de New York</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Alabama"><name sortKey="Hogan, Robert J" sort="Hogan, Robert J" uniqKey="Hogan R" first="Robert J." last="Hogan">Robert J. Hogan</name>
</region>
<name sortKey="Bell, Peter" sort="Bell, Peter" uniqKey="Bell P" first="Peter" last="Bell">Peter Bell</name>
<name sortKey="Boyer, Julie" sort="Boyer, Julie" uniqKey="Boyer J" first="Julie" last="Boyer">Julie Boyer</name>
<name sortKey="Crystal, Ronald G" sort="Crystal, Ronald G" uniqKey="Crystal R" first="Ronald G." last="Crystal">Ronald G. Crystal</name>
<name sortKey="Flieder, Douglas" sort="Flieder, Douglas" uniqKey="Flieder D" first="Douglas" last="Flieder">Douglas Flieder</name>
<name sortKey="Guangping Gao" sort="Guangping Gao" uniqKey="Guangping Gao" last="Guangping Gao">GUANGPING GAO</name>
<name sortKey="Kobinger, Gary P" sort="Kobinger, Gary P" uniqKey="Kobinger G" first="Gary P." last="Kobinger">Gary P. Kobinger</name>
<name sortKey="Paragas, Jason" sort="Paragas, Jason" uniqKey="Paragas J" first="Jason" last="Paragas">Jason Paragas</name>
<name sortKey="Rowe, Thomas" sort="Rowe, Thomas" uniqKey="Rowe T" first="Thomas" last="Rowe">Thomas Rowe</name>
<name sortKey="Voss, Thomas G" sort="Voss, Thomas G" uniqKey="Voss T" first="Thomas G." last="Voss">Thomas G. Voss</name>
<name sortKey="Wilson, James M" sort="Wilson, James M" uniqKey="Wilson J" first="James M." last="Wilson">James M. Wilson</name>
<name sortKey="Wivel, Nelson A" sort="Wivel, Nelson A" uniqKey="Wivel N" first="Nelson A." last="Wivel">Nelson A. Wivel</name>
</country>
<country name="Canada"><noRegion><name sortKey="Feldmann, Heinz" sort="Feldmann, Heinz" uniqKey="Feldmann H" first="Heinz" last="Feldmann">Heinz Feldmann</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires stat1

Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires stat1

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